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2 edition of Climbing behaviour induced by apomorphine in mice found in the catalog.

Climbing behaviour induced by apomorphine in mice

Virinder Nohria

Climbing behaviour induced by apomorphine in mice

a potential model for the detection of neuroleptic activity.

by Virinder Nohria

  • 129 Want to read
  • 16 Currently reading

Published by The author in Bradford .
Written in English


Edition Notes

M.Sc. dissertation.

SeriesDissertations
The Physical Object
Pagination53p.
Number of Pages53
ID Numbers
Open LibraryOL21484060M

In vivo Studies Effect of MMS on Apomorphine-Induced Climbing Behavior in Mice. Methanolic extract of Mitragyna speciosa (50– mg/kg, p.o.) showed significant inverted bell-shaped inhibitory response on apomorphine-induced climbing time [F(7,56) = ; p climbing behavior [F(7,56) = ; p Cited by: 6.   Protais P, Costentin J, Schwartz JC (). Climbing behaviour induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum. Psychopharmacology 1–6. CAS; ArticleCited by:

Apomorphine–Induced Rearing and Climbing. This test measures rearing and climbing induced by apomorphine. The test has predictive validity for antipsychotic drugs that normalize the hyperactivity and stereotypic behavior. Antipsychotic agents decrease rearing and climbing behaviors in mice.   Lessened sensitivity to apomorphine induced climbing behavior in mice following neonatal exposure to phenobarbital. Yanai J, Feigenbaum JJ, Fishman RH. Neurobehav Toxicol Teratol, 4(5), 01 Sep Cited by: 4 articles | PMID: Author: Brus R, Kruk Z, Wesołowska M, Stanosek B.

  In the present study, we examined the potential role of NMDA receptors in the glutamatergic modulation of dopaminergic function at the postsynaptic dopamine receptor by determining the effects of NMDA antagonists on apomorphine-induced climbing behavior in mice. The noncompetitive NMDA receptor antagonists, MK, ketamine, dextrorphan, and Cited by:   In agreement with a previous report (Moore and Axton, ), treatment with the combination of D1 and D2 dopamine agonists induced climbing behavior in mice (F (6,39) = , p apomorphine-induced by:


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Climbing behaviour induced by apomorphine in mice by Virinder Nohria Download PDF EPUB FB2

The mouse climbing model, as induced by apomorphine, is forwarded as a test with potential to detect antipsychotic agents not only of the classical type but also agents of novel activity by: Apomorphine and the putative dopamine agonist, 2-(N,N-dipropyl)-amino-5,6-dihydroxytetralin induced dose-dependent climbing behaviour in the mouse which was measured in wire mesh lined cages as the percentage of time spent climbing in the 30 min period following the first climb and as the maximum time spent in a single climb throughout the drug by:   Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum.

Protais P, Costentin J, Schwartz JC. Mice treated with low doses of apomorphine tend to adopt a vertical position along the walls of their cage. Optimal conditions have been defined to obtain a reliable dose-response by: Abstract Apomorphine (ap) was administered subcutaneously to mice kept in individual cages.

Ap elicited an abnormal vertical climbing behaviour. The muscarinomimetics physostigmine and oxotremorine as well as the neuroleptics clozapine and haloperidol inhibited the climbing produced by ap 1 Cited by: 7.

Abstract. Mice treated with low doses of apomorphine tend to adopt a vertical position along the walls of their cage. Optimal conditions have been defined to obtain a reliable dose-response relationship.

This peculiar behavior appears to be elicited by stimulation of dopamine receptors in the striatum: it is suppressed after coagulation of this structure while it is facilitated when these receptors Cited by: The climbing behaviour in mice was used for studying possible interaction(s) of d-LSD with dopamine receptors Doses of d-LSD ranging from 0, Author: Jean-Yves Sovilla, Pierre Magistretti, Michel Schorderet.

Apomorphine and the putative dopamine agonist, 2-(N, N-dipropyl)-amino-5, 6-dihydroxytetralin induced dose-dependent climbing behaviour in the mouse which was measured in wire mesh lined cages as the percentage of time spent climbing in the 30 min period following the first climb and as the maximum time spent in a single climb throughout the drug by: 1.

The climbing behaviour in mice was used for studying possible interaction(s) of d-LSD with dopamine receptors. Doses of d-LSD ranging from to mg/kg injected intra-peritoneally constantly inhibited the climbing behaviour.

In contrast, when similar doses of d-LSD were injected 10 min before apomorphine (5 mg/kg), a constant potentiation of the apomorphine-induced climbing Author: Jean-Yves Sovilla, Pierre Magistretti, Michel Schorderet.

Surprisingly, a potentiation of apomorphine-induced climbing behaviour was found in d-LSD treated mice with a maximal effect at 1 mg/kg. Similar concentrations of d-LSD alone (Fig. 1) did not induce any climbing behaviour. On the contrary, d-LSD alone inhibits the normal behaviour of con- trol : Jean-Yves Sovilla, Pierre Magistretti, Michel Schorderet.

Apomorphine-induced climbing behaviour in mice. Administration of apomorphine to mice results in a peculiar climbing behaviour characterized initially by rearing and then spontaneous climbing activity. A cylindrical metal cage (18×19 cm) consisting of vertical (1 cm apart) and horizontal ( cm apart) metal bars (2 mm) with upper lid was used in the present by: In this study, the ability of S-(+)-apomorphine (S-(+)-APO) to antagonize R-(−)-APO-induced stereotypic cage-climbing behavior in mice was investigated.

Initial studies using a racemic mixture showed a depression of the cage-climbing behavior relative to that expected if S-(+)-APO were merely by: apomorphine-induced climbing behavior in mice has been correlated with neuroleptic potentials (Protais et al., ; Costall et al., a), and this test has been used for decades as a screening.

The acute and chronic effects of estradiol benzoate were studied on apomorphine-induced climbing behavior in intact female mice. Climbing behavior was measured by determining the maximum climbing time and climbing index. Mice pretreated with estradiol benzoate ( or mg/kg, SC) for or 24 hours prior to apomorphine administration showed no significant difference in climbing behavior when Cited by: 4.

Climbing behavior induced by peripherally administered apomorphine in the mouse was reduced by –10 μg bilateral intra-accumbens fluphenazine, (±) and (-) sulpiride and by serotonin, but not by (+)sulpiride, dl-propranolol, phentolamine, atropine or methysergide. A specific antagonism of climbing could not be shown when fluphenazine was injected into the striatum, hypothalamus, Cited by: DBA2 mice show an erratic spontaneous climbing which is reduced by increasing doses of direct dopamine agonists (apomorphine up to 5 mg/kg, piribedil up to 20 mg/kg).

Sustained stereotyped climbing occurs when animals are treated with l-dopa plus benserazide and dexamphetamine. In this strain, which is spontaneously insensitive to apomorphine-induced climbing, this behaviour.

Apomorphine-induced stereotypic cage climbing in mice as a model for studying changes in dopamine receptor sensitivity.

Wilcox RE, Smith RV, Anderson JA, Riffee WH. We have previously confirmed in mice that apomorphine (APO) induces dopamine specific stereotypic cage by: The dopaminergic agonist apomorphine produced dose‐dependent stereotypic climbing behavior in mice housed in cages with vertical bars.

Differential effects of morphine, DPDPE, and U on apomorphine-induced climbing behavior in μ-opioid receptor knockout mice Article in Molecular Brain Research 94() November induced sleep, amphetamine–induced stereotype behaviour and apomorphine–induced climbing in mice.

Materials and Methods Animals. All experiments performed on laboratory animals in this study followed the ‘‘Principles of laboratory animal care’’ (NIH Publication, ). Swiss albino mice (20–25 g each) and WistarCited by: 9.

Administration of apomorphine hydrochloride ( mg kg-1 s.c.) to adult male or female Wistar rats previously acclimatized to the test environment induced climbing behaviour in approximately 50% of animals examined.

The proportion of animals climbing was related to age, being maximal at by:. The experimental conditions allowing to elicit by administration of dopamine agonists a climbing behavior in rats, apparently analogous to the stereotyped cage climbing behavior previously described in mice (Protais et al.

), have been established. Among the various strains of rats studied i.e. Sprague-Dawley, Long Evans and Wistar, the latters were selected as the most responsive to the Cited by: In the apomorphine climbing test, it was found that mirtazapine (–22 mg/kg) did not change the climbing behaviour of mice induced by 1 mg/kg of apomorphine.

However, when given as a co-treatment with haloperidol, mirtazapine (1 and 10 mg/kg) dose-dependently augmented the inhibiting effect of haloperidol on this climbing by: Influence of lunasin on amphetamine-induced hyperactivity (A) and apomorphine-induced climbing behaviour (B) in C57Bl/6 mice.

Amphetamine (Amp) mg/kg i.p. .